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Baldness Biology
 Male pattern baldness overview
 Female pattern baldness overview
 Male pattern baldness presentation
 Female baldness presentation
 Hair fiber in pattern baldness
 Hair follicles in pattern baldness
 Androgen hormones in men
 Androgen hormones in women
 Androgen receptors in baldness
 5 alpha reductase in baldness
 Inflammation in baldness
 Genetics in pattern baldness
 Diseases associated with baldness
 Pattern baldness in children
Baldness Treatments
 Minoxidil for pattern baldness
 Minoxidil for female baldness
 Minoxidil for male baldness
 Finasteride for male baldness
 Finasteride for female baldness
 Tretinoin for pattern baldness
 Diazoxide for pattern baldness
 Ketoconazole for pattern baldness
 Antiandrogens for pattern baldness
 Contraceptives for female baldness
 Spironolactone for female baldness
 Flutamide for female baldness
 Cyproterone acetate for baldness
Coronary artery disease

There has been an indication that bald men have a higher risk for coronary artery disease than men who are not bald. Several documented studies carried out by researchers thereafter have revealed that there is a possible clinical association between pattern baldness and coronary artery disease (CAD) in men. However, the relationship between pattern baldness and coronary artery disease in men is still a controversial issue.

  • Lesko and colleagues documented a case-controlled study of 655 men aged 21 to 54 admitted to the hospital with their first myocardial infarction (heart attack). They were compared with patients of similar age admitted for non-cardiac conditions who did not have a history of prior cardio-vascular problems. The team observed that the vertex (top of the head) but not frontal baldness was associated with an increased risk of myocardial infarction, which increased with the extent of vertex baldness. The age-adjusted relative risk of a myocardial infarction was 1.3 for mild to moderate vertex baldness and 3.4 for severe vertex baldness.
  • In a 12-year follow-up of 11,674 men between 30 to 79 years of age, found that both vertex and especially fronto-parietal baldness was associated with increased risk of myocardial infarction.(Schonhr et al)
  • One of the largest studies during an 11-year period showed an association between severity of baldness and coronary artery disease. A retrospective cohort study of 19,112 male physicians 40 - 84 years old who were free of congestive heart disease at baseline and who completed a questionnaire visually matching hair loss with pictorial representations of baldness was carried out by these researchers. It was found that men with male pattern baldness had an increased risk of coronary artery disease (relative risk for frontal loss 1.09 and severe vertex loss 1.36). (Lotufo et al.)
  • Herrera and colleagues reported on 2017 men in the Framingham study who were assessed in 1956 and 1962 for extent of baldness and observed for 30 years for any cardiovascular disease. The results showed that although the extent of baldness was not correlated with coronary artery disease, the amount of and progression of baldness was associated with the occurrence of coronary artery disease.
  • Although the study of Ford and colleagues found baldness to be not associated with an increased total rate of coronary artery disease incidence or mortality, in men younger than age 55, severe baldness was positively associated with coronary artery disease mortality and somewhat less associated with incidence.
  • In another study on heart disease risk factors concluded that patients with fronto-occipital baldness had on the average higher levels of serum cholesterol and blood pressure compared to participants of similar age with no baldness. (Trevisan et al)

Prostate cancer

It is not exactly clear if androgen is involved or is a primary factor in prostate cancer etiology. However, it can be seen that both male pattern baldness and prostate cancer are both androgen dependent in their processes. Several studies have been conducted to establish the relation of the two conditions, and it has been suggested that the variability in the 5aR-2 gene is the potential explanation for the variability in prostate cancer and male pattern baldness.

Conditions and Diseases Associated With Baldness in Women

The association between pattern baldness and coronary artery disease in men is popular and has been well documented, however, there are but few studies, if any, have focused on this association in women. In women, instead of the coronary artery disease, the association in hair loss was with iron deficiency.

Another is Polycystic ovary syndrome. It is a hormonal imbalance that can lead to irregular menstruations, acne, excess body hair, and weight gain. Women who have this syndrome are more likely to develop androgenic alopecia.

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