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Baldness Treatments
 Minoxidil for pattern baldness
 Minoxidil for female baldness
 Minoxidil for male baldness
 Finasteride for male baldness
 Finasteride for female baldness
 Tretinoin for pattern baldness
 Diazoxide for pattern baldness
 Ketoconazole for pattern baldness
 Antiandrogens for pattern baldness
 Contraceptives for female baldness
 Spironolactone for female baldness
 Flutamide for female baldness
 Cyproterone acetate for baldness

Two percent (2%) topical Minoxidil, the only FDA-approved agent for female pattern hair loss treatment, showed efficacy over placebo in many trials.

  • Investigator global assessment determined – through a well-designed 32-week study – that the application of 2% Minoxidil twice-daily stimulated mild to moderate re-growth in 63% of 157 women treated with Minoxidil compared to 39% of 151 women treated with vehicle.
  • Non-vellus hair counts on the top of the scalp of 256 women aged 15 to 45 years suffering Ludwig I or II alopecia treated with 2% topical Minoxidil showed a mean increase of 14 percent over baseline compared with 7.3 percent for those on placebo. Results were taken from a 32-week trial period.
  • To assess the efficacy and safety of 2% topical Minoxidil solution for the treatment of pattern baldness in women, 10 European centers conducted a 32-week, double-blind, placebo-controlled trial; results led to the conclusion that topical Minoxidil solution was significantly more effective than placebo in the treatment of pattern baldness in women. The mean increase in the non-vellus hair count in the 2% percent Minoxidil group was 33 hairs, significantly greater than that of 19 hairs in the placebo group. Investigators saw 44 percent new growth of those treated with topical Minoxidil and only 29 percent of those on placebo.

The outcome on women with hyperandrogenism may not be as positive however. FDA-controlled studies on women showed no evidence of increased effectiveness of the 5% solution. No significant difference in scalp coverage could be appreciated by investigator global assessment in a 48-week, well-designed comparative efficacy study of the 5% versus the 2% topical Minoxidil in the treatment of mild to moderate female pattern hair loss. Patient satisfaction with the use of the higher concentration, however, was appreciably greater. Using higher concentration in women showed modest benefit at best, and its use should only be considered in those cases that show minimal response to the 2 percent formulation; as shown by subsequent studies.

Studies using hair counts as a primary endpoint in the evaluation of female pattern hair loss have shown a mean increase in hair growth of 15-33% in the Minoxidil-treated goops compared to the 9-14% increase in the vehicle groups. On the other hand, a one small study using hair weights as the endpoint found an increase of 42.5% in hair weights in the Minoxidil group compared to the 1.9% in the control group. Minoxidil was superior over the vehicle in the investigator and subject assessments. However, 40 percent of the subjects appeared not to respond to Minoxidil. It’s also important to note that none of these trials were extended over 32 weeks, and the long-term results of Minoxidil treatment are uncertain. The beneficial effects on hair growth on men are lost rapidly on cessation of treatment and it is most likely that the same effect will hold true in the case of women.

Dosage and application of Minoxidil on female pattern hair loss

Effective dose of Minoxidil solution is one milliliter (25 drops) – must be used twice daily applied directly onto a dry scalp and then slightly spread with the fingers. Regardless of the extent of the affected area, however, dosage should not exceed 2ml everyday. Make 5 partings of the hair and put 5 drops in each part for best application.

Clinical side effects of Minoxidil treatment in female hair loss

Topical application on normal intact skin with Minoxidil is not well absorbed; only 0.3 to 43.5 percent reaches the systematic circulation, which is eliminated out of the system within 4 days from application. However, the effects on absorption of concomitant occlusion and the systematic metabolic biotransformation of topically applied Minoxidil are mostly unknown.

Contact dermatitis (scalp irritation, dryness, itching, scaling, and redness) is the most common side effects of Minoxidil. Hypertrichosis – excessive growth of hair in areas normally not hairy, a side effect of Minoxidil uncommon to men, was known to affect 3 to 5% of women using Minoxidil. It’s unclear why hypertrichosis occurs, but it is possibly through either a systemic effect or via transfer of the drug. Areas commonly affected are the forehead, malar areas, and sides of the face. This condition, however, may diminish with continued treatment over the course of a year, or it resolves completely within a few months once treatment is stopped. Predisposing factors of hypertrichosis are existing facial hairs, higher dosage, and old age over 50 years. Care should be taken to avoid manual spread of the agent by pillows to sites other than the scalp, but local absorption is still believed to be the cause of the problem.

Change in blood pressure or any other systematic effects of Minoxidil solution was not evident from studies done, but patients with cardiovascular disease are advised to use the agent with caution. Pregnant and lactating mothers are also advised to avoid using the product. Although there is no evidence of teratogenicity in rats and rabbits, but the Minoxidil has been found to be secreted through breast milk.

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